VAULONT Sophie & VIOLLET Benoit : UMR_S1016 - UMR8104 : Energy and iron sensing in pathophysiology

Unit : INSERM UMR_S1016 CNRS UMR8104 Institut Cochin - Université Paris Descartes

Institut Cochin
Faculté de médecine Paris Descartes
Equipe "Energy and iron sensing in pathophysiology"
24 rue du Faubourg Saintt Jacques
75014 PARIS

Speciality : Department BCMPP

Director of the unit : Pierre Olivier COURAUD

Principal investigator :

VAULONT Sophie & VIOLLET Benoit
Email : sophie.vaulontSPAMFILTER@inserm.fr Phone number: +33 (0)1 44 41 24 47 / +33 (0)1 44 41 24 01

Composition of research team :

  • VAULONT Sophie (DR1)
  • VIOLLET Benoit (DR2, HDR)  
  • FORETZ Marc (CR1)  
  • LECLERC Jocelyne (IR2)

5 Recent publications of the research team :

Mounier R, Théret M, Arnold L, Cuvellier S, Bultot L, Göransson O, Sanz N, Ferry A, Sakamoto K, Foretz M, Viollet B, Chazaud B. AMPKalpha1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration. Cell Metab. 2013 Aug 6;18(2):251-64.

Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ.Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature. 2013 Feb 14;494(7436):256-60.

Lenoir A, Deschemin JC, Kautz L, Ramsay AJ, Roth MP, Lopez-Otin C, Vaulont S, Nicolas G.Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6. Blood. 2011 Jan 13;117(2):647-50

Foretz M, Hébrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, Sakamoto K, Andreelli F, Viollet B. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest. 2010 Jul 1;120(7):2355-69.

Mastrogiannaki M, Matak P, Keith B, Simon MC, Vaulont S, Peyssonnaux C . HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest. 2009 May;119(5):1159-66