Unit : INSERM UMR_S1016 CNRS UMR 8104 Institut Cochin - Université Paris Descartes

Institut Cochin
Faculté de Médecine Paris Descartes - Site Cochin
Equipe "Génomique et signalisation des tumeurs endocrines"
24 rue du Faubourg Saint-Jacques
75014 PARIS

Speciality : Department DGNRV

Director of the unit : Pierre-Olivier COURAUD

Principal investigator :

BERTHERAT Jérôme
Email : jerome.bertheratSPAMFILTER@cch.aphp.fr	Phone number: +33 (0)1 58 41 18 95

Composition of research team :

• BERTHERAT Jérôme ( PU-PH, HDR)           
• RAGAZZON Bruno (CR1-INSERM, HDR)         
• RIZK-RABBIN Marthe (CR1-CNRS, HDR)            
• GROUSSIN Lionel (PU-PH, HDR) 
• TISSIER Frédérique ( MCU-PH, HDR)     
• ASSIE Guillaume (PHU, HDR)  
• LIBE Rossella ( PH)       
• DOUSSET Bertrand (PU-PH,HDR)      
• BERTAGNA Xavier (PU-PH, HDR)

5 Recent publications of the research team :

Louiset E, Duparc C, Young J, Renouf S, Tetsi Nomigni M, Boutelet I, Libé R,Bram Z, Groussin L, Caron P, Tabarin A, Grunenberger F, Christin-Maitre S,Bertagna X, Kuhn JM, Anouar Y, Bertherat J, Lefebvre H. Intraadrenalcorticotropin in bilateral macronodular adrenal hyperplasia. N Engl J Med. 2013Nov 28;369(22):2115-25. doi: 10.1056/NEJMoa1215245. PubMed PMID: 24283225.

Assié G, Libé R, Espiard S, Rizk-Rabin M, Guimier A, Luscap W, Barreau O,Lefèvre L, Sibony M, Guignat L, Rodriguez S, Perlemoine K, René-Corail F,Letourneur F, Trabulsi B, Poussier A, Chabbert-Buffet N, Borson-Chazot F,Groussin L, Bertagna X, Stratakis CA, Ragazzon B, Bertherat J. ARMC5 mutations inmacronodular adrenal hyperplasia with Cushing's syndrome. N Engl J Med. 2013 Nov 28;369(22):2105-14. doi: 10.1056/NEJMoa1304603. PubMed PMID: 24283224.

Ragazzon B, Libé R, Gaujoux S, Assié G, Fratticci A, Launay P, Clauser E,Bertagna X, Tissier F, de Reyniès A, Bertherat J. Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressiveadrenocortical cancers. Cancer Res. 2010 Nov 1;70(21):8276-81. doi:10.1158/0008-5472.CAN-10-2014. Epub 2010 Oct 19. PubMed PMID: 20959480.

Ragazzon B, Cazabat L, Rizk-Rabin M, Assie G, Groussin L, Fierrard H,Perlemoine K, Martinez A, Bertherat J. Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGFbeta-stimulated apoptosis in adrenocortical cells. Cancer Res. 2009 Sep15;69(18):7278-84. doi: 10.1158/0008-5472.CAN-09-1601. Epub 2009 Sep 8. PubMedPMID: 19738044.

de Reyniès A, Assié G, Rickman DS, Tissier F, Groussin L, René-Corail F,Dousset B, Bertagna X, Clauser E, Bertherat J. Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictorsof malignancy and survival. J Clin Oncol. 2009 Mar 1;27(7):1108-15. doi:10.1200/JCO.2008.18.5678. Epub 2009 Jan 12. PubMed PMID: 19139432.