FUMAGALLI Stefano : UMR_S1151 UMR8253 : Effects of alterations of ribosome biogenesis on cellular homeostasis

Unit : INSERM UMR_S1151 CNRS UMR8253 Institut Necker Enfants Malades (INEM) Université Paris Descartes

Institute Necker Enfants Malades (INEM)
Faculté de Médecine Paris Descartes
14 Rue Maria Helena Vieira da Silva
75993 PARIS cedex

Speciality : Department BCMPP

Director of the unit : Xavier NASSIF

Principal investigator :

Email : stefano.fumagalliSPAMFILTER@inserm.fr Phone number: +33 (0)1 72 60 63 83

Composition of research team :

  • FUMAGALLI Stefano (DR2 INSERM, HDR)    

5 Recent publications of the research team :

RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity. Mol. Cell. Biol. Dec; 33(23):4660-71

Lopez-Pelaez  M, Fumagalli S, Sanz C, Herrer, C, Guerra S, Fernandez M, and Alemany, S. (2012). Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like Receptors-activated macrophages. Mol. Biol. Cell. Aug; 23(15):2982-92.

Fumagalli S*, Ivanenkov V V, Teng T, and Thomas G. (2012) Supra-induction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint. Genes Dev, May 15;26(10):1028-40.* Corresponding author

Fumagalli S*, Di Cara A,   Gulati Neb-A , Natt F,  Schwemberger S, Hall J , Babcock G F, Bernardi R, Pandolfi P P, and Thomas G. (2009)  Absence of Nucleolar Disruption Following Impairment of 40S Ribosome Biogenesis Reveals an rpL11 Translational-dependent Mechanism of p53-induction. Nat. Cell. Biol. Apr; 11(4):501-08. Comment in Nature. 2009 May 7;459(7243):46-7.Selected by Faculty of 1000 Biology.* Corresponding author


Fumagalli S. and Thomas G. (2011). The role of p53 in ribosomopathies. Semin. Hematol. Apr; 48(2):97-105