DONNADIEU Emmanuel et RANDRIAMAMPITA Clotilde : UMR_1016 UMR8104 : Dynamics of T cell interactions

Unit : INSERM UMR_S1016 CNRS URA8104 - Institut Cochin - Université Paris Descartes

Institut Cochin
Equipe Dynamique des interactions lymphocytaires T
22 rue Méchain
75014 Paris

mail du codirecteur : clotilde.randriamampita@inserm.fr

Speciality : Department IMMUNO

Director of the unit : Pierre-Olivier COURAUD

Principal investigator :

DONNADIEU Emmanuel et RANDRIAMAMPITA Clotilde
Email : emmanuel.donnadieuSPAMFILTER@inserm.fr Phone number: +33 (0)1 40 51 65 64 (E. Donnadieu) +33 (0)1 40 51 65 50 (C. Randriamampita)

Composition of research team :

  • DONNADIEU Emmanuel (DR2-CNRS,HDR)  
  • RANDRIAMAMPITA Clotilde (CR1-CNRS,HDR)
  • BERCOVICI Nadège (CR1 CNRS,HDR) 
  • BISMUTH Georges (DR1-INSERM,HDR)
  • CHARVET Céline (CR1-CNRS, HDR)
  • DELON Jérôme (CR1-INSERM, HDR)
  • FEUILLET Vincent (CR1-INSERM, HDR)
  • MANGENEY Marianne (CR1-CNRS, HDR)
  • TRAUTMANN Alain (DRCE-CNRS, Emérite)

5 Recent publications of the research team :

Rougerie,P., Largeteau, Q., Megrelis, 1., Carrette. F., Leieune, T., Toffali, 1., Rossi, 8., Zeghouf, M., Cherfils, J., Constantin, G., Laudanna, C., Bismuth, G., Mangenev, M., Delon, J. (2013) Fam65b is a new transcriptional target of FOXOl that regulates RhoA signaling for T lymphocyte  migration. J lmmunoly 19O(2):748-755.

Salmon, H., Franciszkiewicz, K., Damotte, D., Dieu-Nosjean, M.C., Validire, P. Trautmann, A., Mami-Chouaib, F. and Donnadieu, E. (2012) Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. J Clin lnvest 122:899-91O.

Wang, S. F., Fouquet, S., Chapon. M., Salmon H, Regnier, F., Labroquere, K., Badoual, C., Damotte, D., Validire, P., Maubec, E., Delongchamps, N.8., Cazes, A., Gibault, 1., Garcette, M., Dieu-Nosjean, M. C., Zerbib, M., Avril, M. F., Prevost-Blondel, A., Randriamampita, C., Trautmann, A., Bercovici, N. (2011) Early T cell signalling is reversibly altered in PD-1 T lymphocytes infiltrating human tumors PLoS One 6:e17621.

Conche, C., Boulla, G., Trautmann, A., Randriamampita. C. (2009) T cell adhesion primes antigen receptorinduced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphale. Immunity 30:33-43.

Asperti-Boursin, F., Real, E., Bismuth, G., Trautmann, A., Donnadieu, E. (2007) CCRT ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase- independent manner J Exp Med 204:1167-79