SCHARFMANN Raphael : UMR_S1016 UMR8104 : Control of pancreatic endocrine cell development

Unit : INSERM UMR_S1016 CNRS UMR8104 Institut Cochin - Université Paris Descartes

Groupe Hospitalier Cochin Port Royal
INSERM UMR_S1016 CNRS UMR8104 Institut Cochin
Bâtiment CASSINI
123 boulevard de l'Hôpital
75014 PARIS

Speciality : Department BCMPP

Director of the unit : Pierre-Olivier COURAUD

Principal investigator :

SCHARFMANN Raphael
Email : raphael.scharfmannSPAMFILTER@inserm.fr Phone number: +33 (0)1 76 53 55 68

Composition of research team :

  • SCHARFMANN Raphael (DR1-INSERM, HDR)       
  • POLAK Michel (PUPH, HDR)        
  • DUVILLIE Bertrand (CR1-INSERM, HDR)      
  • ALBAGLI Olivier (CR1-CNRS)       
  • BELTRAND Jacques (MCUPH )   

5 Recent publications of the research team :

Scharfmann R, Pechberty S, Hazhouz Y, von Bülow M, Bricout-Neveu E, Grenier-Godard M, Guez F, Rachdi L, Lohmann M, Czernichow P, Ravassard P. A conditionally immortalized human pancreatic beta cell line. J Clin Invest 2014 124:2087-98.

Capito C, Simon MT, Aiello V, Clark A, Aigrain Y, Ravassard P, Scharfmann R. The mouse muscle as an ectopic permissive site for human pancreatic development. Diabetes. 2013 62:3479–3487.

Soggia A, Flosseau K. Ravassard P, Szinnai G, Scharfmann R, Guillemain G. Activation of the transcription factor carbohydrate-responsive element-binding protein by glucose leads to increased pancreatic beta cells differentiation. Diabetologia 2012 55:2713-22.

Rachdi L, Aïello V, Duvillié B, Scharfmann R. L-Leucine Alters Pancreatic β-Cell Differentiation and Function via the mTor Signaling Pathway. Diabetes. 2012 61:409-17.

Ravassard P, Hazhouz Y, Pechberty S, Bricout-Neveu E, Armanet M, Czernichow P, Scharfmann R. A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion. J Clin Invest. 2011 121:3589-97.