FREMEAUX-BACCHI Véronique : UMR_S1138 : Complement and diseases
Unit : INSERM UMR_S1138 - Centre de Recherches des Cordeliers - Université Pierre et Marie Curie et Univeristé Paris Descartes
Centre de Recherche des Cordeliers
INSERM UMR_S1138
Equipe 10 " Complément et Maladies"
15 rue de l'Ecole de Médecine
75006 PARIS
Speciality : Department IMMUNO
Director of the unit : Pascal FERRE
Principal investigator :
FREMEAUX-BACCHI Véronique | |
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Email : veronique.fremeaux-bacchiSPAMFILTER@epg.aphp.fr | Phone number: +33 (0)1 56 09 39 47 |
Composition of research team :
- FREMEAUX-BACCHI Véronique (PH /Contrat d’interface INSERM,HDR)
- DRAGON-DUREY Marie Agnes (MCU-PH, HDR)
- ROUMENINA Lubka (CR)
5 Recent publications of the research team :
Lemaire M, Fremeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nurnberg G, Altmuller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nurnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP: Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Nat Genet 45:531-6, 2013
Frimat M, Tabarin F, Dimitrov JD, Poitou C, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT: Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome. Blood 122:282-92, 2013
Le Quintrec M, Zuber J, Moulin B, Kamar N, Jablonski M, Lionet A, Chatelet V, Mousson C, Mourad G, Bridoux F, Cassuto E, Loirat C, Rondeau E, Delahousse M, Fremeaux-Bacchi V: Complement genes strongly predict recurrence and graft outcome in adult renal transplant recipients with atypical hemolytic and uremic syndrome. Am J Transplant 13:663-75, 2013
Blanc C, Roumenina LT, Ashraf Y, Hyvarinen S, Sethi SK, Ranchin B, Niaudet P, Loirat C, Gulati A, Bagga A, Fridman WH, Sautes-Fridman C, Jokiranta TS, Fremeaux-Bacchi V, Dragon-Durey MA: Overall neutralization of complement factor H by autoantibodies in the acute phase of the autoimmune form of atypical hemolytic uremic syndrome. J Immunol 189:3528-37, 2012
Roumenina LT, Frimat M, Miller EC, Provot F, Dragon-Durey MA, Bordereau P, Bigot S, Hue C, Satchell SC, Mathieson PW, Mousson C, Noel C, Sautes-Fridman C, Halbwachs-Mecarelli L, Atkinson JP, Lionet A, Fremeaux-Bacchi V: A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain-of-function. Blood 119:4182-91, 2012