SAP Jan : UMR7216 : Cell signaling and neural fate

Unit : CNRS UMR7216 "Epigénétique et destin cellulaire" Université Paris Diderot

Université Paris Diderot
CNRS UMR 7216  Epigénétique et destin cellulaire
Bâtiment Lamarck
Case 7042
35 rue Hélène Brion
75205 PARIS cedex 13

Speciality : Department DGNRV

Director of he unit : Jonathan WEITZMAN

Principal investigator :

SAP Jan
Email : jan.sapSPAMFILTER@univ-paris-diderot.fr Phone number: +33 (0)1 57 27 89 16

Composition of research team :

  • SAP Jan (PR, HDR)
  • DUBREUIL Véronique (MCF)  

5 Recent publications of the research team :

M Truffi, V Dubreuil, X Liang, N Vacaresse, GA Gomez, F Nigon, AS Yap and J Sap: Receptor protein tyrosine phosphatase RPTP controls epithelial adherens junctions, linking E-cadherin engagement to c-Src signaling to cortactin. J. Cell Sci (2014) in press.

M Ambjørn, V Dubreuil, F Miozzo, F Nigon, B Møller, S Issazadeh-Navikas, J Berg, M Lees, and J Sap: (2013) A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. PLoS ONE 8(6): e65371. doi:10.1371/journal.pone.0065371

N Takahashi, KS Nielsen, B Aleksic, S Petersen, M Ikeda, I Kushima, N Vacaresse, H Ujike, N Iwata, V Dubreuil, N Mirza, T Sakurai, N Ozaki, JD Buxbaum, and J Sap (2011):  Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase  to schizophrenia.Biological Psychiatry 70, 626-635.

G. Tamguney, K. Giles, D.V. Glidden, P. Lessard, H. Wille, P. Tremblay, D.F. Groth, F. Yehiely, C. Korth, R.C. Moore, J. Tatzelt, E. Rubenstein, C. Boucheix, P. Stanley, M.P. Lisanti, R.A. Dwek, P.M. Rudd, S.S. Sisodia, J. Moskovitz, C.J. Epstein, T.C. Dawson Cruz, W.A. Kuziel, N. Maeda, J. Sap, K. Hsiao Ashe, G.A. Carlson, I. Tesseur, T. Wyss-Coray, L. Mucke, K.H. Weisgraber, R.W. Mahley, F.E. Cohen, and S.B. Prusiner (2008) : Genes contributing to prion pathogenesis. Journal of General Virology 89, 1777-1788. 

N Vacaresse, B Møller, EM Danielsen, M Okada, and J Sap: (2008) Activation of c-Src and Fyn kinases by protein tyrosine phosphatase RPTP is substrate-specific and compatible with lipid raft localization  J. Biol. Chem. 283, 35815-35824.