SAP Jan : UMR7216 : Cell signaling and neural fate
Unit : CNRS UMR7216 "Epigénétique et destin cellulaire" Université Paris Diderot
Université Paris Diderot
CNRS UMR 7216 Epigénétique et destin cellulaire
Bâtiment Lamarck
Case 7042
35 rue Hélène Brion
75205 PARIS cedex 13
Speciality : Department DGNRV
Director of he unit : Jonathan WEITZMAN
Principal investigator :
SAP Jan | |
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Email : jan.sapSPAMFILTER@univ-paris-diderot.fr | Phone number: +33 (0)1 57 27 89 16 |
Composition of research team :
- SAP Jan (PR, HDR)
- DUBREUIL Véronique (MCF)
5 Recent publications of the research team :
M Truffi, V Dubreuil, X Liang, N Vacaresse, GA Gomez, F Nigon, AS Yap and J Sap: Receptor protein tyrosine phosphatase RPTP controls epithelial adherens junctions, linking E-cadherin engagement to c-Src signaling to cortactin. J. Cell Sci (2014) in press.
M Ambjørn, V Dubreuil, F Miozzo, F Nigon, B Møller, S Issazadeh-Navikas, J Berg, M Lees, and J Sap: (2013) A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. PLoS ONE 8(6): e65371. doi:10.1371/journal.pone.0065371
N Takahashi, KS Nielsen, B Aleksic, S Petersen, M Ikeda, I Kushima, N Vacaresse, H Ujike, N Iwata, V Dubreuil, N Mirza, T Sakurai, N Ozaki, JD Buxbaum, and J Sap (2011): Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase to schizophrenia.Biological Psychiatry 70, 626-635.
G. Tamguney, K. Giles, D.V. Glidden, P. Lessard, H. Wille, P. Tremblay, D.F. Groth, F. Yehiely, C. Korth, R.C. Moore, J. Tatzelt, E. Rubenstein, C. Boucheix, P. Stanley, M.P. Lisanti, R.A. Dwek, P.M. Rudd, S.S. Sisodia, J. Moskovitz, C.J. Epstein, T.C. Dawson Cruz, W.A. Kuziel, N. Maeda, J. Sap, K. Hsiao Ashe, G.A. Carlson, I. Tesseur, T. Wyss-Coray, L. Mucke, K.H. Weisgraber, R.W. Mahley, F.E. Cohen, and S.B. Prusiner (2008) : Genes contributing to prion pathogenesis. Journal of General Virology 89, 1777-1788.
N Vacaresse, B Møller, EM Danielsen, M Okada, and J Sap: (2008) Activation of c-Src and Fyn kinases by protein tyrosine phosphatase RPTP is substrate-specific and compatible with lipid raft localization J. Biol. Chem. 283, 35815-35824.