PENDE Mario : UMR_S1151 UMR8253 : Cell growthcontrol by nutrients

Unit : INSERM UMR_S1151 - CNRS UMR8253 - Institut Necker Enfants Malades (INEM) - Université Paris Descartes

Institut Necker Enfants Malades (INEM)
INSERM UMR_S1151 CNRS UMR8253
Equipe "Contrôle de la croissance cellulaire par les nutriments"
Université Paris Descartes
Bâtiment Leriche - porte 9
14 rue Maria Helena Vieira Da Silva CS 61431
75993 PARIS Cedex 14

Speciality : Department DGNRV

Director of the unit : Xavier NASSIF

Principal investigator :

PENDE Mario
Email : mario.pendeSPAMFILTER@inserm.fr Phone number: +33 (0)1 72 60 63 86

Composition of research team :

  • PENDE Mario (DR1-INSERM, HDR)
  • de KEYZER Yves (DR2-INSERM, HDR)  
  • CAILLAUD Catherine (MCU-PH, HDR) 
  • PUGET Stephanie (PU-PH, HDR)
  • PANASYUK Ganna (CR1)
  • NEMAZANYY Ivan (Enseignant associé)

5 Recent publications of the research team :

Nemazanyy I., Blaauw B., Paolini C., Caillaud C., Protasi F., Mueller A., Proikas-Cezanne T., Russell R.C., Guan K-L., Nishino I., Sandri M., Pende M.*, Panasyuk G. (2013) *corresponding author. Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease. EMBO Mol Med, 5, 870-890. doi: 10.1002/emmm.201202057.

Panasyuk G., Espeillac C., Chauvin C., Pradelli L.A., Horie Y., Suzuki A., Annicotte J.S., Fajas L., Foretz M., Verdeguer F., Pontoglio M., Ferré P., Scoazec J.Y., Birnbaum M.J., Ricci J.E., Pende M. (2012) PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nature Communications, 3:672. doi: 10.1038/ncomms1667.

Espeillac C., Mitchell C., Celton-Morizur S., Chauvin C., Koka V., Gillet C., Albrecht J.H., Desdouets C., Pende M. (2011) S6 kinase 1 activity is required for rapamycin-sensitive liver proliferation after mouse hepatectomy. Journal of Clinical Investigation, 121, 2821-2832.

Alliouachene S., Tuttle R.L., Boumard S., Lapointe T., Berissi S., Germain S., Jaubert F., Tosh D., Birnbaum M.J., Pende M. (2008) Constitutively active Akt1 expression in mouse pancreas requires S6 Kinase 1 for insulinoma formation. Journal of Clinical Investigation, 118, 3629-3638.

Aguilar V., Alliouachene S., Sotiropoulos A., Sobering A., Athea Y., Djouadi F., Miraux S., Thiaudière E., Foretz M., Viollet B., Diolez P., Bastin J., Benit P., Rustin P., Carling D., Sandri M., Ventura-Clapier R., Pende M. (2007) S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metabolism, 5, 476-487.