DESDOUETS Chantal : UMR_S1016 UMR8104 : Cell Cycle and Liver Physiopathology

Unit : INSERM UMR_S1016 CNRS UMR8104 Institut Cochin - Université Paris Descartes

Institut Cochin
Département Développement Reproduction Cancer
24 rue du Faubourg St Jacques
75014 PARIS

Speciality : Department BCMPP

Director of the unit : Pierre-Olivier COURAUD

Principal investigator :

DESDOUETS Chantal
Email : chantal.desdouetsSPAMFILTER@inserm.fr Phone number: +33 (0)1 44 41 24 39

Composition of research team :

  • DESDOUETS Chantal (DR2-INSERM, HDR) 
  • CELTON-MORIZUR Séverine (CR2-INSERM)
  • COUTY Jean Pierre (MCF, HDR)

5 Recent publications of the research team :

Merlen G, Gentric G, Celton-Morizur S, Foretz M, Guidotti JE, Fauveau V, Leclerc J, Viollet B, Desdouets C.(2014). AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression. J. Hepatol. 60 (1) : 152-59.

Anson M, Crain-Denoyelle A, Baud V, Chereau F, Gougelet A, Terris B, Yamagoe S, Colnot S, Viguier M,  Perret C and Couty JP.(2012). Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice. J Clin Invest, 122(2):586-99.

Espeillac C*, Mitchell C*, Celton-Morizur S*, Chauvin C, Koka V, Gillet C, Albrecht JH, Desdouets C, Pende M. (2011). S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy. J Clin Invest, 121 (7): 2821-32. (*Equal contribution)

Celton-Morizur S, Merlen G, Couton D, Margall-Ducos G, Desdouets C.(2009). The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents. J Clin Invest, 119(7): 1880-87.

Margall-Ducos G, Celton-Morizur S, Couton D, Bregerie O, Desdouets C. (2007). Liver tetraploidization is controlled by a new process of incomplete cytokinesis. J Cell Science, 120(20): 3633-39.