van ENDERT Peter : UMR_S1151 UMR8253 : Antigen presentation by MHC molecules : mechanisms and impact of Toll-like receptors

Unit : INSERM UMR_S1151 CNRS UMR8253 Institut Necker Enfants-Malades (INEM) Université Paris Descartes

Hôpital Necker
INSERM UMR_S1151 CNRS UMR8253
Bâtiment Hamburger
149 rue de Sèvres
75015 PARIS

Speciality : Department IMMUNO

Director of the unit : Xavier NASSIF

Principal investigator :

van ENDERT Peter
Email : peter.van-endertSPAMFILTER@inserm.fr Phone number: +33 (0)1 44 49 25 63

Composition of research team :

  • VAN ENDERT Peter (PU-PH1, HDR)  
  • MANOURY Bénédicte (DR2-CNRS,HDR) 
  • DIANA Julien (CR2-INSERM, HDR)

 

5 Recent publications of the research team :

Sun J, Furio L, Mecheri R, van der Does AM, Lundeberg E, Saveanu L, van Endert P, Agerberth B, Diana J. Pancreatic b-cells express a cathelicidin-related antimicrobial peptide regulating autoimmune diabetes. Immunity 43 (2015): 304-17

Weimershaus M, Evnouchidou I, Saveanu L, van Endert P. Peptidases trimming MHC class I ligands. Curr. Opin. Immunol. 25 (2013) : 90-96

Maschalidi S, Hassler S, Balanc F, Sepulveda FE, Tohme M, Chignard M, van Endert P, Si-Tahar M, Descamps D, Manoury B. Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation. PLoS Pathogens e1002841 (2012).

Enée E, Kratzer R, Arnoux JB, Barilleau E, Hamel Y, Marchi C, Beltrand J, Michaud B, Chatenoud L, Robert J-J, van Endert P. ZnT8 is a major CD8+ T cell-recognized anutoantigen in pediatric type 1 diabetes. Diabetes 61 (2012): 1779-84

Saveanu L, Carroll O, Weimershaus M, Guermonprez P, Firat E, Lindo V, Greer F, Davoust J, Kratzer R, Keller SR, Niedermann G, van Endert P. IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science 325 (2009): 213-7