PRETOLANI Marina : UMR_S1152 : Airway inflammation and remodeling in chronic obstructive pulmonary diseases

Unit : INSERM UMR_S1152 "Physiopathologie et Epidémiologie des Maladies Respiratoires " Université Paris Diderot

UFR de Médecine Xavier Bichat
INSERM UMR_S1152 "Physiopathologie et Epidémiologie des Maladies Respiratoires "
16 rue Henri Huchard
75018 PARIS

Speciality : Department BCMPP

Director of the unit : Marina PRETOLANI

Principal investigator :

PRETOLANI Marina
Email : marina.pretolaniSPAMFILTER@inserm.fr Phone number: +33 (0)1 57 27 75 86

Composition of research team :

  • PRETOLANI Marina (DR1-INSERM, HDR) 
  • AUBIER Michel (PU-PH-EX, HDR)
  • BRUGIERES Olivier (PH)   
  • CLERICI Christine (PU-PH-EX, HDR)   
  • CASTIER Yves (PU-PH1, HDR)   
  • DANEL Claire (MCU-PH)
  • DOMBRET Marie-Christine (PH) 
  • LEROY Pascale (CR1-CNRS) 
  • LETUVE Séverine (MCF)
  • MORDANT Pierre (MCU-PH)
  • TAILLE Camille (MCU-PH)

5 Recent publications of the research team :

Ferhani N, Létuvé S, Kozhich A, Thibaudeau O, Grandsaigne M, Maret M, Dombret MC, Sims GP, Kolbeck R, Coyle AJ, Aubier M, Pretolani M. Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010 May 1;181(9):917-27.

Létuvé S, Kozhich A, Humbles A, Brewah Y, Dombret MC, Grandsaigne M, Adle H, Kolbeck R, Aubier M, Coyle AJ, Pretolani M. Lung chitinolytic activity and chitotriosidase are elevated in chronic obstructive pulmonary disease and contribute to lung inflammation. Am J Pathol. 2010 Feb;176(2):638-49.

Létuvé S, Kozhich A, Arouche N, Grandsaigne M, Reed J, Dombret MC, Kiener PA, Aubier M, Coyle AJ, Pretolani M. YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages. J Immunol. 2008 Oct 1;181(7):5167-73.

Druilhe A, Zahm JM, Benayoun L, El Mehdi D, Grandsaigne M, Dombret MC, Mosnier I, Feger B, Depondt J, Aubier M, Pretolani M. Epithelium expression and function of retinoid receptors in asthma. Am J Respir Cell Mol Biol. 2008 Mar;38(3):276-82.

Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M,* Elias JA*. A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med. 2007 Nov 15;357(20):2016-27. * co-senior authors