DENTIN Renaud : Nutrients, metabolism and transcriptional response : Nutrients, metabolism and transcriptional response

Unité de recherche : Institut Cochin INSERM U1016, CNRS UMR8104, Université Paris Descartes

Institut Cochin, Faculté de médecine

24 rue du Faubourg Saint Jacques

75014 Paris

Spécialité : Département BCMPP

Directeur de l'unité de rattachement : COURAUD Pierre-Olivier

Responsable de l'équipe de recherche :

DENTIN Renaud
Courriel : renaud.dentinSPAMFILTER@inserm.fr Tel: 01.53.73.27.20

Composition de l'équipe de recherche :

  • DENTIN Renaud (CR1 INSERM, HDR)
  • LEVAVASSEUR Françoise (IR2 - INSERM)
  • TOPCU Selin (AI)
  • SEFFOU Bolaji (AI)
  • CHRISTODOULOU Eleni (PostDoc)
  • MULLER David (PostDoc)

5 publications récentes de l'équipe de recherche :

Dentin R, Benhamed F, Pégorier JP, Foufelle F, Viollet B, Vaulont S, Girard J, Postic C. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest. 2005 Oct;115(10):2843-54.

 

Bricambert J, Miranda J, Benhamed F, Girard J, Postic C, Dentin R. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest. 2010 Dec;120(12):4316-31.

 

Dentin R, Tomas-Cobos L, Foufelle F, Leopold J, Girard J, Postic C, Ferré P. Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver. J Hepatol. 2012 Jan;56(1):199-209.

 

Dentin R, Langin D, Postic C. Hidden variant of ChREBP in fat links lipogenesis to insulin sensitivity. Cell Metab. 2012 Jun 6;15(6):795-7.

 

Solenne Marmier, Renaud Dentin, Martine Daujat-Chavanieu, Hervé Guillou, Justine Bertrand-Michel, Sabine Gerbal-Chaloin, Jean Girard, Sophie Lotersztajn and Catherine Postic. Novel role for ChREBP in the control of ethanol metabolism and susceptibility to binge drinking. Hepatology. 2015 Oct;62(4):1086-100.