FUMAGALLI Stefano : UMR_S1151 UMR8253 : Inhibition de la biogenèse ribosomales: effets sur l’ homéostasie cellulaire et implications pathologiques

Unité de recherche : INSERM UMR_S1151 CNRS UMR8253 Institut Necker Enfants Malades (INEM) Université Paris Descartes

Institute Necker Enfants Malades (INEM)
Faculté de Médecine Paris Descartes
14 Rue Maria Helena Vieira da Silva
CS61431
75993 PARIS cedex

Spécialité : Département BCMPP

Directeur de l'unité de rattachement : Xavier NASSIF

Responsable de l'équipe de recherche :

FUMAGALLI Stefano
Courriel : stefano.fumagalliSPAMFILTER@inserm.fr Tel: 01 72 60 63 83

Composition de l'équipe de recherche :

  • FUMAGALLI Stefano (DR2 INSERM, HDR)     

5 publications récentes de l'équipe de recherche :

RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity. Mol. Cell. Biol. Dec; 33(23):4660-71

Lopez-Pelaez  M, Fumagalli S, Sanz C, Herrer, C, Guerra S, Fernandez M, and Alemany, S. (2012). Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like Receptors-activated macrophages. Mol. Biol. Cell. Aug; 23(15):2982-92.

Fumagalli S*, Ivanenkov V V, Teng T, and Thomas G. (2012) Supra-induction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint. Genes Dev, May 15;26(10):1028-40.* Corresponding author

Fumagalli S*, Di Cara A,   Gulati Neb-A , Natt F,  Schwemberger S, Hall J , Babcock G F, Bernardi R, Pandolfi P P, and Thomas G. (2009)  Absence of Nucleolar Disruption Following Impairment of 40S Ribosome Biogenesis Reveals an rpL11 Translational-dependent Mechanism of p53-induction. Nat. Cell. Biol. Apr; 11(4):501-08. Comment in Nature. 2009 May 7;459(7243):46-7.Selected by Faculty of 1000 Biology.* Corresponding author

Reviews

Fumagalli S. and Thomas G. (2011). The role of p53 in ribosomopathies. Semin. Hematol. Apr; 48(2):97-105