RAUTOU Pierre-Emmanuel : Time window control of inflammation by canonical and non-canonical endothelial autophagy to prevent fatty liver disease progression : Contrôle temporal de l’inflammation par l’autophagie endothéliale canonique et non canonique pour prévenir la progression de la stéatopathie métabolique

Unité de recherche : INSERM UMR_S1149 ERL 8252 – Centre de Recherche sur l’inflammation (CRI)

Centre de Recherche sur l'Inflammation (CRI)
 UFR de Médecine Xavier Bichat
 16 rue Henri Huchard
 75890 PARIS Cedex 18

Spécialité : Département BCMPP

Directeur de l'unité de rattachement : Renato MONTEIRO

Responsable de l'équipe de recherche : RAUTOU Pierre-Emmanuel

RAUTOU Pierre-Emmanuel
Courriel : pierre-emmanuel.rautouSPAMFILTER@inserm.fr Tel: +33.1.40.87.52.83

Composition de l'équipe de recherche :

Senior Scientists (INSERM/CNRS)

H GILGENKRANTZ (DR), A HABIB (CR), P LETTERON (CR),

S LOTERSZTAJN (DR), MOREAU (DR)

Senior Scientists/ Clinicians (University/Hospital)

L CASTERA (Pr-PH), F DURAND (PU-PH), C FRANCOZ (PH), C PAUGAM BURTZ (PU-PH), A PLESSIER (PH), PE RAUTOU (PU-PH), O SOUBRANE (PU-PH), D VALLA (PU-PH), E WEISS (MCU-PH)

Engineers (University/INSERM)

N Pilard –Marques, J Wan

Students and post-docs

P Hegde, D Chohr, S Bajewa, M Allaire, M Mabire, F Dramé

5 publications récentes de l'équipe de recherche :

  1. Loyer X, Paradis V, Hénique C, Vion AC, Colnot N, Guerin CL, Devue C, On S, Scetbun J, Romain M, Paul JL, Rothenberg ME, Marcellin P, Durand F, Bedossa P, Prip-Buus C, Baugé E, Staels B, Boulanger CM, Tedgui A, Rautou PE. Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression. Gut. 2016 Nov;65(11):1882-1894. (OA; impact factor 2016: 16.7)
  2. Poisson J, Lemoinne S, Boulanger C, Durand F, Moreau R, Valla D, Rautou PE. Liver sinusoidal endothelial cells: physiology and role in liver diseases. J Hepatol. 2017 Jan;66(1):212-227.  (RA; impact factor 2016: 12.5)
  3. Bissonnette J, Altamirano J, Devue C, Roux O, Payance A, Lebrec D, Bedossa P, Valla D, Durand F, Ait-Oufella H, Sancho-Bru P, Caballeria J, Boulanger CM, Bataller R, Rautou PE. Plasma cytokeratin-18 fragments are an accurate non-invasive tool for the diagnosis of severe alcoholic hepatitis. Hepatology. 2017 Aug;66(2):555-563 (OA; impact factor 2016: 13.2)
  4. Vion AC*, Kheloufi M*, Hammoutene A, Poisson J, Lasselin J, Devue C, Pic I, Dupont N, Busse J, Starke K, Lafaurie-Janvore J, Barakatf AI,  Loyer X, Souyri M, Viollet B, Julia P, Tedgui A, Codogno P, Boulanger CM*, Rautou PE*. Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8675-E8684 (OA; impact factor 2016: 9.7)
  5. Payancé A, Silva-Junior G, Bissonnette J, Tanguy M, Pasquet B, Levi C, Roux O, Nekachtali O, Baiges A, Hernández-Gea V, Laouénan C, Lebrec D, Albuquerque M, Paradis V, Moreau R, Valla D, Durand F, Boulanger CM, Garcia-Pagan JC, Rautou PE. Hepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis. Hepatology. 2018 Mar 30 (OA; impact factor 2016: 13.2)